Comparison of inhibitory effects of glucosamine and mannosamine on bovine articular cartilage degradation in vitro.

@article{Mello2004ComparisonOI,
  title={Comparison of inhibitory effects of glucosamine and mannosamine on bovine articular cartilage degradation in vitro.},
  author={David M Mello and Brian D Nielsen and Tonia L Peters and John Caron and Michael W. Orth},
  journal={American journal of veterinary research},
  year={2004},
  volume={65 10},
  pages={
          1440-5
        }
}
  • David M Mello, Brian D Nielsen, +2 authors Michael W. Orth
  • Published 2004
  • Biology, Medicine
  • American journal of veterinary research
  • OBJECTIVE To compare the inhibitory effects of glucosamine and mannosamine on articular cartilage degradation and the effects on chondrocyte viability in vitro. SAMPLE POPULATION Bovine articular cartilage explants. PROCEDURES Explants were cultured in commercial medium for 48 hours. Cartilage was exposed to medium containing 10% fetal bovine serum, 10 microg of lipopolysaccharide/mL, and 0.5, 1.0, 2.5, 5.0, and 10.0 mg of glucosamine or mannosamine/mL for 24 hours. Nitric oxide (NO… CONTINUE READING

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