Comparison of infarct-derived and control ovine cardiac myofibroblasts in culture: response to cytokines and natriuretic peptide receptor expression profiles.

@article{Jarvis2006ComparisonOI,
  title={Comparison of infarct-derived and control ovine cardiac myofibroblasts in culture: response to cytokines and natriuretic peptide receptor expression profiles.},
  author={Martin D. Jarvis and Miriam T Rademaker and Leigh J. Ellmers and Margaret J. Currie and Judith L McKenzie and Barry R. Palmer and C M Frampton and Arthur Mark Richards and Vicky A. Cameron},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2006},
  volume={291 4},
  pages={
          H1952-8
        }
}
This study investigated whether gene expression profiles of myofibroblasts derived from infarcted myocardium differ from normal cardiac fibroblasts. We compared the expression of cytoskeletal proteins in cultured ovine cardiac fibroblasts derived from infarcted (ID) and noninfarcted ovine myocardium (NID) and the levels of expression of the natriuretic peptide receptors (NPR)-A and NPR-B in response to treatment with transforming growth factor (TGF)-beta1 and/or platelet-derived growth factor… 
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Cardiac fibroblasts: at the heart of myocardial remodeling.
Congestive Heart Failure Effects on Atrial Fibroblast Phenotype: Differences between Freshly-Isolated and Cultured Cells
TLDR
Fresh-isolated CHF and control atrial fibroblasts display distinct ECM-gene and morphological differences consistent with in vivo pathology, and demonstrate potentially-important atrial-fibroblast phenotype changes in CHF.
Enhanced Fibroblast–Myocyte Interactions in Response to Cardiac Injury
TLDR
These data demonstrate cardiac injury results in significant electrophysiological changes that enhance fibroblast–myocyte interactions and could contribute to the greater incidence of arrhythmias observed in fibrotic hearts.
Mechanical stretch up-regulates the B-type natriuretic peptide system in human cardiac fibroblasts: a possible defense against transforming growth factor-β mediated fibrosis
TLDR
It is postulate that stretch induced up-regulation of the natriuretic peptide system may contribute to the observed reduction in myofibroblast differentiation.
Melatonin-induced augmentation of collagen deposition in cultures of fibroblasts and myofibroblasts is blocked by luzindole--a melatonin membrane receptors inhibitor.
Remodeling of cardiac fibroblasts following myocardial infarction results in increased gap junction intercellular communication.
The Cardiac Fibroblast: Functional and Electrophysiological Considerations in Healthy and Diseased Hearts
TLDR
The functional changes associated with fibroblast activation, the membrane currents that have been identified in adult cardiac fibroblasts, and recent studies of fibro Blast-myocyte electrical interactions are described to generate new therapeutic approaches for the prevention of arrhythmias associated with cardiac fibrosis.
Age-related divergent remodeling of the cardiac extracellular matrix in heart failure: collagen accumulation in the young and loss in the aged.
The miR-21 / PDCD 4 / AP-1 feedback loop function as a driving force for renal fibrogenesis
TLDR
MiR-21 is a main driving force of fibroblast activation and keeps its high expression level by employing a double negative autoregulatory loop, and Targeting this aberrantly activated feedback loop may provide new therapeutic strategy in treating fibrotic kidneys.
The feedback loop between miR-21, PDCD4 and AP-1 functions as a driving force for renal fibrogenesis
TLDR
Anti-miRNA-21 oligonucleotides prevent progression of renal fibrosis by blocking the auto-regulatory loop between miR-21, PDCD4 and AP-1 during myofibroblast activation.
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References

SHOWING 1-10 OF 42 REFERENCES
Differentiation of Cardiac Fibroblasts to Myofibroblasts During 1 β Stimulation of Collagen Production by Transforming Growth Factor-Print
TLDR
The data suggest that TGF1-stimulated collagen production in cultures of adult rat cardiac ventricular fibroblasts cannot be explained by a direct stimulation of the collagen production either in fibro Blasts or in myofibroblast, which have a higher activity for collagen production than fibroBlasts.
Atrial (ANP) and brain natriuretic peptide (BNP) expression after myocardial infarction in sheep: ANP is synthesized by fibroblasts infiltrating the infarct.
TLDR
This is the first report of ANP expression and synthesis by cardiac fibroblasts invading the fibrotic scar, suggesting that ANP may be involved in regulating fibroblast proliferation during reparative fibrosis.
Expression of functional angiotensin-converting enzyme and AT1 receptors in cultured human cardiac fibroblasts.
TLDR
The presence of local ACE and AT1 receptors in human fibroblasts suggests their involvement in the development of cardiac fibrosis.
Cardiac myofibroblasts isolated from the site of myocardial infarction express endothelin de novo.
  • L. Katwa
  • Biology
    American journal of physiology. Heart and circulatory physiology
  • 2003
TLDR
C cultured myoFbs express and generate ET-1 and receptor-mediated modulation of type I collagen expression by ET, which suggests a major role for ET in tissue repair following myocardial infarct (MI).
Gene expression, secretion, and autocrine action of C-type natriuretic peptide in cultured adult rat cardiac fibroblasts.
TLDR
It is demonstrated that CNP is synthesized in and secreted from cardiac fibroblasts and suggested that C NP has a suppressive effect on fibroblast proliferation and extracellular matrix production, probably via the guanylyl cyclase-B-mediated cGMP-dependent process.
Brain natriuretic peptide appears to act locally as an antifibrotic factor in the heart.
TLDR
It is postulate that BNP acts as a cardiocyte-derived antifibrotic factor in the ventricle in response to acute cardiac pressure overload induced by aortic constriction.
Locally applied GM-CSF induces the accumulation of α-smooth muscle act in containing myofibroblasts
TLDR
Results suggest that locally applied cytokines induce the formation of distinct granulation tissues, and in particular, GM-CSF stimulates a-SM actin synthesis in myofibroblasts, illustrating an unexpected extra-hematopoietic in vivo effect of this factor.
Natriuretic peptide receptor-B in adult rat ventricle is predominantly confined to the nonmyocyte population.
TLDR
Fibroblasts are likely the most responsive cell type (cGMP production) in the adult rat heart, and Fibroblast of cardiac origin do not show an interactive relationship between receptor responsiveness to CNP, cGMP levels, and proliferation-related mitogen-activated signal transduction pathways.
Effects of transforming growth factor-beta 1 on human arterial smooth muscle cells in vitro.
  • S. Björkerud
  • Biology
    Arteriosclerosis and thrombosis : a journal of vascular biology
  • 1991
TLDR
Investigating the degree of myodifferentiation in terms of the presence of differentiation-specific filamentous alpha-smooth muscle actin and growth of SMCs found that exposure to the mitogens, platelet-derived growth factor and epidermal growth factor, and the bifunctional growth factor-beta 1 indicated a dedifferentiating effect by these mitogens.
Inhibitory regulation of hypertrophy by endogenous atrial natriuretic peptide in cultured cardiac myocytes.
TLDR
It is suggested that endogenous ANP inhibits cardiac myocyte hypertrophy under basal and PE-stimulated conditions, probably through a cGMP-dependent process.
...
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3
4
5
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