Comparison of inducibility of sulfotransferase and UDP-glucuronosyltransferase mRNAs by prototypical microsomal enzyme inducers in primary cultures of human and cynomolgus monkey hepatocytes.

@article{Nishimura2008ComparisonOI,
  title={Comparison of inducibility of sulfotransferase and UDP-glucuronosyltransferase mRNAs by prototypical microsomal enzyme inducers in primary cultures of human and cynomolgus monkey hepatocytes.},
  author={Masuhiro Nishimura and Akiko Koeda and Takefumi Shimizu and Mitsuo Nakayama and Tetsuo Satoh and Shizuo Narimatsu and Shinsaku Naito},
  journal={Drug metabolism and pharmacokinetics},
  year={2008},
  volume={23 1},
  pages={45-53}
}
We investigated the change of the mRNA levels of sulfotransferase and UDP-glucuronosyltransferase isoforms by the prototypical microsomal enzyme inducers rifampicin (Rif), dexamethasone (Dex), and omeprazole (Ome) in primary cultures of cryopreserved human and cynomolgus monkey hepatocytes. Real-time RT-PCR analysis was performed using primers and TaqMan… CONTINUE READING