Comparison of in vivo and in vitro measures of beryllium sensitization.

  title={Comparison of in vivo and in vitro measures of beryllium sensitization.},
  author={C A Bobka and Luke A. Stewart and G J Engelken and Loren E Golitz and Lee S. Newman},
  journal={Journal of occupational and environmental medicine},
  volume={39 6},
Chronic beryllium disease (CBD) diagnosis hinges on demonstrating a cell-mediated immune response to beryllium salts in vitro with the beryllium lymphocyte proliferation test (BeLPT). The BeLPT has found widespread application in screening for CBD and beryllium sensitization in populations of exposed workers. We hypothesized that the in vivo beryllium salt patch test may be of value as an adjunct to the BeLPT, rectifying false negative or ambiguous blood test results. We studied subjects with… CONTINUE READING

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