Comparison of in vivo and in vitro binding of polycyclic hydrocarbons to DNA.

@article{Eastman1978ComparisonOI,
  title={Comparison of in vivo and in vitro binding of polycyclic hydrocarbons to DNA.},
  author={A. Eastman and John W. Sweetenham and E. Bresnick},
  journal={Chemico-biological interactions},
  year={1978},
  volume={23 3},
  pages={345-53}
}
The in vivo binding of [3H]benzo(a)pyrene (BP) and 3-[3H]methylcholanthrene (3MC) to liver and lung DNA was studied in A/J mice. Only in liver was there any reduction in total DNA-bound radioactivity between 4 h and 24 h after administration of the hydrocarbon. DNA was fractionated on Sephadex LH-20 after enzymatic digestion. A single deoxyribonucleoside-BP adduct was detected whereas two major 3MC-adducts were observed. Wtih both BP and 3MC, three additional peaks of radioactivity eluted… CONTINUE READING

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