Comparison of in vitro methods to determine drug-induced cell lethality.

  title={Comparison of in vitro methods to determine drug-induced cell lethality.},
  author={Paul R. Roper and Benjamin Drewinko},
  journal={Cancer research},
  volume={36 7 PT 1},
In proliferating cell populations, the inability to reproduce indefinitely is the only relevant criterion to assess cell lethality. The in vitro colony formation technique (CF) used to determine reproductive death is, however, too slow and has several technical limitations. For finding suitable, more rapid techniques that assessed drug-induced cell killing, a human lymphoma cell line was exposed in vitro to increasing concentrations of adriamycin, bleomycin, and 1,3-bis(2-chloroethyl)-1… CONTINUE READING
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