Comparison of in vitro metabolism of ticlopidine by human cytochrome P450 2B6 and rabbit cytochrome P450 2B4.

@article{Talakad2011ComparisonOI,
  title={Comparison of in vitro metabolism of ticlopidine by human cytochrome P450 2B6 and rabbit cytochrome P450 2B4.},
  author={Jyothi C. Talakad and Manish B Shah and Gregory S. Walker and Cathie Xiang and James R. Halpert and Deepak K. Dalvie},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2011},
  volume={39 3},
  pages={
          539-50
        }
}
A recent X-ray crystal structure of a rabbit cytochrome P450 2B4 (CYP2B4)-ticlopidine complex indicated that the compound could be modeled with either the thiophene or chlorophenyl group oriented toward the heme prosthetic group. Subsequent NMR relaxation and molecular docking studies suggested that orientation with the chlorophenyl ring closer to the heme was the preferred one. To evaluate the predictive value of these findings, the oxidation of ticlopidine by reconstituted CYP2B4 was studied… CONTINUE READING

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