Comparison of in vitro immunostimulatory potential of live and inactivated influenza viruses.

@article{Blazevic2000ComparisonOI,
  title={Comparison of in vitro immunostimulatory potential of live and inactivated influenza viruses.},
  author={Vesna Blazevic and Charles Mac Trubey and Gene M. Shearer},
  journal={Human immunology},
  year={2000},
  volume={61 9},
  pages={845-9}
}
Live influenza viruses, heat-inactivated virus, and a trivalent formalin-inactivated influenza vaccine were analyzed for their in vitro stimulatory properties on immune cells from healthy donors. Lymphocyte proliferation induced by each influenza antigen was comparable. Influenza vaccine stimulated significantly lower production of interferon-gamma (IFN-gamma) compared with live and heat inactivated viruses, whereas both vaccine and heat-inactivated influenza induced lower levels of IFN-alpha… CONTINUE READING