Comparison of in vitro dialysis release methods of loperamide-encapsulated liposomal gel for topical drug delivery

@inproceedings{Hua2014ComparisonOI,
  title={Comparison of in vitro dialysis release methods of loperamide-encapsulated liposomal gel for topical drug delivery},
  author={S. Jack Hua},
  booktitle={International journal of nanomedicine},
  year={2014}
}
BACKGROUND The purpose of this study was to determine the most appropriate dialysis equilibrium method to assess liposomal gel formulations containing hydrophobic drugs, to give the most accurate indication of drug release. METHODS Loperamide hydrochloride-encapsulated liposomes, composed of L-α-phosphatidylcholine and cholesterol (molar ratio of 2:1), were prepared according to the method of dried lipid film hydration. The liposomes were incorporated into a carbopol gel (0.5%, weight/weight… CONTINUE READING