Comparison of in vitro and in vivo biological activity of mycotoxins.

  title={Comparison of in vitro and in vivo biological activity of mycotoxins.},
  author={P S Terse and M. S. Madhyastha and O V Zurovac and David A Stringfellow and Ronald R. Marquardt and Barbara W Kemppainen},
  journal={Toxicon : official journal of the International Society on Toxinology},
  volume={31 7},
In vitro assays developed to screen the cytotoxic activity of chemicals in murine (NIH/3T3) and bovine (BE 12-6) embryonic cells were used to determine the concentrations (microgram/ml) of mycotoxins which caused 50% lethality (LC50). Embryonic cells were seeded in 96 well plates, cultured for 72 hr with dilutions of each individual and combinations of mycotoxins, and stained and counted. Verrucarin A and roridin A had the strongest cytotoxic activity, and ergotamine tartrate was least toxic… CONTINUE READING

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