Comparison of in situ and peripheral host immunity to syngeneic tumours employing the multicellular spheroid model.

  • Edith M. Lord
  • Published 1980 in The British journal of cancer. Supplement


The multicellular tumour spheroid was used as a model system to assess the in situ host immune response to the EMT6/Ro mammary tumour in syngeneic BALB/cKa mice. In sensitized mice the spheroids were rapidly infiltrated by host cells including macrophages, lymphocytes and granulocytes. Tumour cell killing was evident within 1 day and resulted in the… (More)


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