Comparison of in Vitro Activity of Cefotaxime and Desacetylcefotaxime Alone and in Combination against 320 Gram-Negative Clinical Isolates

@article{Pidrola1988ComparisonOI,
  title={Comparison of in Vitro Activity of Cefotaxime and Desacetylcefotaxime Alone and in Combination against 320 Gram-Negative Clinical Isolates},
  author={Dr G. Pi{\'e}drola and I. C. Rodriguez Galan and Ahid{\'e}e Leyva and Mar{\'i}a Del Carmen Maroto},
  journal={Drugs},
  year={1988},
  volume={35},
  pages={62-64}
}
The antimicrobial activity of cefotaxime and its intermediate metabolite, desacetylcefotaxime, against 320 Gramnegative bacterial strains was analysed to investigate whether combination of the 2 substances led to increased bactericidal activity. The in vitro study of the minimum inhibitory concentration (MIC) showed the combination to be more effective against Escherichia coli, Klebsiella spp., Enterobacter spp. and Proteus mirabilis, requiring <50% of the concentration of cefotaxime alone to… CONTINUE READING