Comparison of immunomodulative effects of histamine-2 receptor antagonists in gastric cancer patients: focus on the lymphoblastogenesis and cytotoxicity of peripheral blood mononuclear cells.

@article{Hahm1994ComparisonOI,
  title={Comparison of immunomodulative effects of histamine-2 receptor antagonists in gastric cancer patients: focus on the lymphoblastogenesis and cytotoxicity of peripheral blood mononuclear cells.},
  author={Ki Baik Hahm and S. I. Lee and Jun Pyo Chung and Won Ho Kim and Jin Hwan Kim and In Suh Park},
  journal={International journal of immunopharmacology},
  year={1994},
  volume={16 12},
  pages={985-93}
}
A proposed mechanism of the immunomodulative effects of histamine-2 receptor antagonist (H2-RA) has been considered to be the inhibition of suppressor T-lymphocyte activity, an increase in interleukin-2 production of helper T-lymphocytes, and an enhancement of natural killer cell activity. Since there is a lack of comparative data about the immunomodulative effects of various H2-RAs, cimetidine, ranitidine and famotidine on peripheral blood mononuclear cells (PBMC), study of the comparison of… CONTINUE READING