Comparison of immunologic restoration and virologic response in plasma, tonsillar tissue, and cerebrospinal fluid in HIV-1-infected patients treated with double versus triple antiretroviral therapy in very early stages: The Spanish EARTH-2 Study. Early Anti-Retroviral Therapy Study.

@article{Garca2000ComparisonOI,
  title={Comparison of immunologic restoration and virologic response in plasma, tonsillar tissue, and cerebrospinal fluid in HIV-1-infected patients treated with double versus triple antiretroviral therapy in very early stages: The Spanish EARTH-2 Study. Early Anti-Retroviral Therapy Study.},
  author={F. J. Mendez Garc{\'i}a and Marta M Alonso and Joan Romeu and Hernando Knobel and Julio Arrizabalaga and Elena Ferrer and David Dalmau and Isabel Ru{\'i}z and F. Javier S{\'a}nchez Vidal and Albert Franc{\'e}s and Ferr{\'a}n Segura and Juan Luis G{\'o}mez-Sirvent and Anna Cruceta and Bonaventura Clotet and Tom{\'a}s Pumarola and Teresa Gallart and William A O'brien and Jose M Mir{\'o} and Jose M. Gatell},
  journal={Journal of acquired immune deficiency syndromes},
  year={2000},
  volume={25 1},
  pages={26-35}
}
The objective of antiretroviral therapy is to obtain an almost complete and durable suppression of viral replication in all compartments to facilitate recovery of the immune system. We assessed the virologic effect in plasma, tonsillar tissue, and cerebrospinal fluid (CSF) in 94 HIV-1-infected patients with CD4 counts >500 x 106 cells per liter and viral load >5000 copies/ml randomly assigned to triple antiretroviral therapy (two nucleoside reverse transcriptase inhibitors (NRTIs) plus one… CONTINUE READING