Comparison of immunohistochemical and fluorescence in situ hybridization assessment for HER-2/neu status in Taiwanese breast cancer patients.

@article{Kuo2007ComparisonOI,
  title={Comparison of immunohistochemical and fluorescence in situ hybridization assessment for HER-2/neu status in Taiwanese breast cancer patients.},
  author={S E Kuo and Boris Bao-Tyan Wang and Cheng-Shyong Chang and Tze-Ho Chen and K L Yeh and D Lee and P A Yin and Ming Chen},
  journal={Taiwanese journal of obstetrics & gynecology},
  year={2007},
  volume={46 2},
  pages={146-51}
}
OBJECTIVE Accurate diagnostic assessment of human epidermal growth factor receptor-2 (HER-2) is essential and a prerequisite for appropriate application of the humanized anti-HER-2 monoclonal antibody trastuzumab (Herceptin) to the treatment of patients with breast cancer. Immunohistochemistry (IHC) is the most widely applicable diagnostic modality in studying HER-2 status. Fluorescence in situ hybridization (FISH) is also recognized as a modality in cases with an equivocal IHC status (score, 2… CONTINUE READING

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