Comparison of immunohistochemical and biochemical assay of steroid receptors in primary breast cancer--clinical associations and reasons for discrepancies.

@article{Chebil2003ComparisonOI,
  title={Comparison of immunohistochemical and biochemical assay of steroid receptors in primary breast cancer--clinical associations and reasons for discrepancies.},
  author={Gunilla Chebil and P{\"a}r-Ola Bendahl and Ingrid Idvall and M{\aa}rten Fern{\"o}},
  journal={Acta oncologica},
  year={2003},
  volume={42 7},
  pages={719-25}
}
Estrogen (ER) and progesterone receptor (PgR) status was analysed in paraffin-embedded breast cancer material with immunohistochemical (IHC) technique and compared with corresponding analyses in cytosols (CYT). ER showed the same status (positive/negative) with both methods in 88% of the samples (352/402). The concordance was also high for PgR status (81% [321/394]). Besides values near cut-off, heterogeneity in the distribution of receptor positive and negative nuclei within a tumour sample… CONTINUE READING
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