Comparison of immunocytochemical and steroid-binding assays for estrogen receptor in human breast tumors.

@article{King1985ComparisonOI,
  title={Comparison of immunocytochemical and steroid-binding assays for estrogen receptor in human breast tumors.},
  author={William J. King and Eugene R Desombre and Elwood V. Jensen and Geoffrey L Greene},
  journal={Cancer research},
  year={1985},
  volume={45 1},
  pages={293-304}
}
An estrogen receptor immunocytochemical assay which uses monoclonal antibodies to the estrogen receptor protein [Nature (Lond.), 307: 745-747, 1984] was applied to several human tissues, including human breast tumors, and the results were compared to those of steroid-binding assays performed on cytosol extracts of the same tissues. Specific immunoperoxidase staining in fixed, frozen sections was confined to the nucleus of selected cell populations within each tissue examined. In 117 human… CONTINUE READING