Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source.

@article{Sakaguchi2005ComparisonOH,
  title={Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source.},
  author={Y. Sakaguchi and I. Sekiya and K. Yagishita and T. Muneta},
  journal={Arthritis and rheumatism},
  year={2005},
  volume={52 8},
  pages={
          2521-9
        }
}
OBJECTIVE To compare the properties of human mesenchymal stem cells (MSCs) isolated from bone marrow, synovium, periosteum, skeletal muscle, and adipose tissue. METHODS Human mesenchymal tissues were obtained from 8 donors during knee surgery for ligament injury. After collagenase digestion or gradient-density separation, nucleated cells were plated at an appropriate density for expansion at the maximum rate without colony-to-colony contact. Yield, expandability, differentiation potential… Expand
Comparison of rat mesenchymal stem cells derived from bone marrow, synovium, periosteum, adipose tissue, and muscle
TLDR
Rat MSCs from synovium-derived cells had the greatest potential for both proliferation and chondrogenesis, indicating their usefulness for cartilage study in a rat model. Expand
Myogenic Properties of Human Mesenchymal Stem Cells Derived from Three Different Sources
TLDR
For the further development of MSC-based treatments of myopathies, AT-MSCs appear to be the best choice in view of their efficient contribution to myoregeneration, their high ex vivo expansion potential, and because their harvesting is less demanding than that of BM- or SM- MSCs. Expand
Comparison of Osteogenic Ability of Rat Mesenchymal Stem Cells from Bone Marrow, Periosteum, and Adipose Tissue
TLDR
Micro-computed tomographic and histological analyses demonstrated that new bone formation was detected in the composites using BMSCs and PMSCs, although it was hard to detect in other composites, which indicates that B MSCs andPMSCs could be ideal candidates for utilization in practical bone tissue regeneration. Expand
Comparison of cellular responses of mesenchymal stem cells derived from bone marrow and synovium on combined silk scaffolds.
  • Haifeng Liu, Xing Wei, +4 authors Yubo Fan
  • Materials Science, Medicine
  • Journal of biomedical materials research. Part A
  • 2015
TLDR
Based on the cellular response in vitro and in vivo, SMSCs may represent a more suitable cell source than BMSCs for further study and development of tissue-engineered ligament. Expand
Equine bone marrow-derived mesenchymal stem cells: optimization of cell density in primary culture.
TLDR
The best density of equine BM-MNCs in primary culture (P0) for obtaining the maximum bone marrow-derived mesenchymal stem cell (BM-MSC) yields at the end of P0 was determined. Expand
Purified Human Synovium Mesenchymal Stem Cells as a Good Resource for Cartilage Regeneration
TLDR
The results show that the tissue from which MSCs are isolated should be tailored according to their intended clinical therapeutic application, and suggest that the synovium tissue contained a significantly larger percentage of LNGFR + THY-1 + M SCs. Expand
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TLDR
Results indicate that cells derived from tissue explant cultures re- served certain degree of differentiation properties of MSCs in vitro. Expand
Skin-derived multipotent stromal cells – an archrival for mesenchymal stem cells
TLDR
Cell populations of adherent and floating spheres derived from different origins of skin, or correctly foreskin, by enzymatic digestion compared with established MSCs are summarized, indicating that the skin-derived adherent cell populations and floating cells can be good alternative sources of progenitor cells especially in cosmetic, plastic and sports regenerative medicine. Expand
Establishment of mesenchymal stem cells derived from bone marrow and synovium of transgenic rats expressing dual reporter genes
TLDR
It is demonstrated that synovium-MSC and bone marrow-MSCs possessed greater chondrogenic ability than other mesenchymal tissue-derived MSCs, indicating that those M SCs are promising cellular sources for cartilage regeneration. Expand
Impact of the source and serial passaging of goat mesenchymal stem cells on osteogenic differentiation potential: implications for bone tissue engineering
TLDR
Low passaged bone marrow MSCs displayed a significantly higher and superior osteogenic potential, and hence, will be the preferred choice for bone tissue engineering in future in vivo experiments, and may require a cell-based enhancer/inducer to improve their osteogenic regenerative capacity. Expand
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