Comparison of human immunodeficiency virus type 1 tropism profiles in clinical samples by the Trofile and MT-2 assays.

@article{Coakley2009ComparisonOH,
  title={Comparison of human immunodeficiency virus type 1 tropism profiles in clinical samples by the Trofile and MT-2 assays.},
  author={Eoin P. G. Coakley and Jacqueline D. Reeves and Wei Huang and Marga Mangas-Ruiz and Irma Maurer and Agnes M. Harskamp and Soumi Gupta and Yolanda Lie and Christos J. Petropoulos and Hanneke Schuitemaker and Ang{\'e}lique B van 't Wout},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 11},
  pages={4686-93}
}
The recent availability of CCR5 antagonists as anti-human immunodeficiency virus (anti-HIV) therapeutics has highlighted the need to accurately identify CXCR4-using variants in patient samples when use of this new drug class is considered. The Trofile assay (Monogram Biosciences) has become the method that is the most widely used to define tropism in the clinic prior to the use of a CCR5 antagonist. By comparison, the MT-2 assay has been used since early in the HIV epidemic to define tropism in… CONTINUE READING

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