Comparison of histocompatibility antigens on cultured human tumor cells and fibroblasts by quantitative antibody absorption and sensitivity to cell-mediated cytotoxicity.

@article{Golub1976ComparisonOH,
  title={Comparison of histocompatibility antigens on cultured human tumor cells and fibroblasts by quantitative antibody absorption and sensitivity to cell-mediated cytotoxicity.},
  author={Sidney H. Golub and Douglas C. Hanson and H L Sulit and Donald L. Morton and Michele A. Pellegrino and Soldano Ferrone},
  journal={Journal of the National Cancer Institute},
  year={1976},
  volume={56 1},
  pages={167-70}
}
Human tumor and febroblast tissue culture cells were compared to determine the suitability of fibroblasts as control cells in experiments on human tumor serology and cellular immunology. Fibroblasts expressed the same HL-A antigen profile as did melanoma cells. Furthermore, the quantitative expression of the determinants was similar on both cell types. In four of five pairs tested, the fibroblasts displayed similar sensitivity to effector cells generated by mixed lymphocyte culture as did the… CONTINUE READING

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