Comparison of hippocampal Deep Brain Stimulation with high (130Hz) and low frequency (5Hz) on afterdischarges in kindled rats

@article{Wyckhuys2010ComparisonOH,
  title={Comparison of hippocampal Deep Brain Stimulation with high (130Hz) and low frequency (5Hz) on afterdischarges in kindled rats},
  author={T. Wyckhuys and R. Raedt and K. Vonck and W. Wadman and P. Boon},
  journal={Epilepsy Research},
  year={2010},
  volume={88},
  pages={239-246}
}
  • T. Wyckhuys, R. Raedt, +2 authors P. Boon
  • Published 2010
  • Medicine
  • Epilepsy Research
  • Hippocampal Deep Brain Stimulation (DBS) is proposed as an experimental treatment for refractory epilepsy, but the optimal stimulation parameters are undetermined. High frequency hippocampal DBS at 130Hz is effective in both animals and patients with epilepsy. Low frequency stimulation (approximately 5Hz) is assumed to have anti-epileptic properties but the efficacy is highly debated. This animal study compares the effects of both stimulation modalities in kindled rats. Sprague Dawley rats (n… CONTINUE READING
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