Comparison of high-dose with low-dose subcutaneous heparin to prevent left ventricular mural thrombosis in patients with acute transmural anterior myocardial infarction.

@article{Turpie1989ComparisonOH,
  title={Comparison of high-dose with low-dose subcutaneous heparin to prevent left ventricular mural thrombosis in patients with acute transmural anterior myocardial infarction.},
  author={Alexander G. G. Turpie and Jennifer G. Robinson and D. J. Doyle and Amin S Mulji and Gregory J. Mishkel and Brian J Sealey and John Cairns and L Skingley and Jack Hirsh and Michael J. Gent},
  journal={The New England journal of medicine},
  year={1989},
  volume={320 6},
  pages={352-7}
}
We performed a double-blind randomized trial comparing high doses of subcutaneous heparin (12,500 units every 12 hours) with low doses (5000 units every 12 hours) for 10 days in the prevention of left ventricular mural thrombosis in 221 patients with acute anterior myocardial infarction. Left ventricular mural thrombosis was observed by two-dimensional echocardiography on the 10th day after infarction in 10 of 95 patients (11 percent) in the high-dose group and in 28 of 88 patients (32 percent… CONTINUE READING

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