Comparison of hepatitis C virus genotyping by 5' noncoding region- and core-based reverse transcriptase PCR assay with sequencing and use of the assay for determining subtype distribution in India.

@article{Lole2003ComparisonOH,
  title={Comparison of hepatitis C virus genotyping by 5' noncoding region- and core-based reverse transcriptase PCR assay with sequencing and use of the assay for determining subtype distribution in India.},
  author={Kavita S. Lole and Jyotsna A. Jha and Sandhya P. Shrotri and Badri Nath Tandon and Vishwa Mohan Prasad and Vidya A Arankalle},
  journal={Journal of clinical microbiology},
  year={2003},
  volume={41 11},
  pages={
          5240-4
        }
}
Phylogenetic analysis of the sequences of the 5' noncoding regions (5'NCR) of 149 samples from hepatitis C virus (HCV) RNA-positive chronic carriers representing northern, southern, eastern, and western India showed that type 3 and type 1 are the predominant genotypes circulating in India, with an overall prevalence of 53.69 and 38.25%, respectively. Type 4 viruses (6.04%) were seen only in southern India. Sequence analysis of the core region of 51 of the above isolates enabled us to classify… CONTINUE READING

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