Comparison of hepatic cathepsin D activity in response to tumor growth and to caloric restriction in mice.

@article{Lundholm1980ComparisonOH,
  title={Comparison of hepatic cathepsin D activity in response to tumor growth and to caloric restriction in mice.},
  author={Kent G Lundholm and Lena Ekman and Ingvar Karlberg and Staffan Edstr{\"o}m and Tore Scherst{\'e}n},
  journal={Cancer research},
  year={1980},
  volume={40 5},
  pages={1680-5}
}
In malignant disease, the caloric intake is often reduced. We have studied the role of this nutritional deprivation in increased lysosomal enzyme activities in liver and muscle tissue in tumorbearing mice. Three study groups were used: Group 1, sarcoma-bearing mice (MCG 101); Group 2, starved mice; Group 3, mice pair fed according to the ad libitum intake of the tumor-bearing animals. Cathepsin D activity (Vmax)was increased in the homogenates of liver tissue in all study groups. /S… CONTINUE READING