Comparison of hematologic consequences and efficacy of p-aminophenones in mice.

@article{Rockwood1999ComparisonOH,
  title={Comparison of hematologic consequences and efficacy of p-aminophenones in mice.},
  author={Gary A. Rockwood and Steven I. Baskin and James A. Romano and Melanie L. Murrow and Joel A. Preville and R. B. Lee and Richard E. Sweeney},
  journal={Environmental toxicology and pharmacology},
  year={1999},
  volume={7 4},
  pages={
          237-52
        }
}
Toxicity in rhesus monkeys following administration of the 8-aminoquinoline 8-[(4-amino-l-methylbutyl)amino]-5-(l-hexyloxy)-6-methoxy-4-methylquinoline (WR242511)
TLDR
It is concluded that WR242511 should not be pursued as a pretreatment for CN poisoning unless the anti-CN characteristics of this compound can be successfully dissociated from those producing undesirable toxicity.
Acute oral toxicity of p‐aminopropiophenone to stoats (Mustela erminea)
TLDR
PAPP toxicosis in stoats appeared relatively rapid (in comparison with other vertebrate pesticides in mustelids) and on preliminary assessment appears relatively humane.
The Effects of WR242511 in Rhesus Monkeys
TLDR
An 8- aminoquinoline drug, WR242511, was characterized as a long-lasting MHb former, producing sufficient MHb to protect against 2 X LD50 of CN.
Neurotoxicological and Behavioral Effects of Cyanide and Its Potential Therapies
The use of the blood agent cyanide (CN) as a military threat agent has been recognized not only historically (Nero and Napoleon III) but also more currently in World War I, World War II, in the

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Effects of P-aminopropiophenone (PAPP), P-aminoheptanoylphenone (PAHP), and P-aminooctanoylphenone (PAOP) Exposure on Methemoglobin, Sulfhemoglobin, Oxyhemoglobin, Oxygen Content, Reduced Hemoglobin, Oxygen Saturation, Carboxyhemoglobin, and Oxygen Capacity in Mice.
TLDR
Describing the hematologic effects of the MHb-forming compound p-aminopropiophenone (PAPP), and two structurally related phenones, p-aminoheptanoylphenone (PAHP) and PAOP, in mice provided information which will be useful for the successful development of improved anti-CN MHb formers.
Effects of Methemoglobin Formers on Spontaneous Locomotor Activity and Methemoglobin Levels in Mice
TLDR
Analysis of locomotor activity effects and MHb formation capacity of three MHb formers with established efficacy against CN support the idea that compounds producing low MHb levels can be effective against CN without debilitating side effects.
Chemically induced methemoglobinemias in the mouse.
The Pharmacology of p-Aminopropiophenone in the Detoxification of Cyanide
TLDR
PAPP is effective as a pretreatment antidote to cyanide when used by single-dose administration but possible chronic hematological and genotoxic effects of PAPP may limit its development in repeated chronic treatment.
The effect of sodium nitrite and para-aminopropriophenone administration on blood methemoglobin levels and red blood cell survival.
TLDR
No significant difference was observed between intragastric and subcutaneous administration either in the time-course or in the maximum level of methemoglobinemia achieved during the administration of sodium nitrite or PAPP to rats.
[Studies of sulfhemoglobin formation by various drugs (3) (author's transl)].
  • A. Nomura
  • Chemistry
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica
  • 1977
TLDR
Sulfhemoglobin and methemoglobinemia was found to be induced by NA even though SHb was not demonstrated with a single administration, and was not observed with MF, CPAA, CPPA and various derivatives of N1 and IG240.
The induction of methaemoglobin by p-aminophenones.
Topical anesthetic‐induced methemoglobinemia and sulfhemoglobinemia in macaques: A comparison of benzocaine and lidocaine
TLDR
It is indicated that benzocaine applied topically in non‐human primates can readily increase MHb concentrations within 30 min to clinically relevant levels required for cyanide prophylaxis, but LC does not.
METHEMOGLOBINEMIA AFTER ADMINISTRATION OF p-AMINOACETOPHENONE AND p-AMINOPROPIOPHENONE
TLDR
Due to the desirable chemical and pharmacological properties of p-aminopropiophenone this compound may prove of value for the experimental production of methemoglobinemia and anoxia.
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