Comparison of hangover effects among triazolam, flunitrazepam and quazepam in healthy subjects: A preliminary report

  title={Comparison of hangover effects among triazolam, flunitrazepam and quazepam in healthy subjects: A preliminary report},
  author={Taro Takahashi and Yuka Okajima and Tempei Otsubo and Junko Shinoda and Masaru Mimura and Kazuyuki Nakagome and Kunitoshi Kamijima},
  journal={Psychiatry and Clinical Neurosciences},
Abstract The aim of the present study was to compare the hangover effects of night‐time administration of triazolam (0.25 mg), flunitrazepam (1 mg) and quazepam (15 mg) in healthy subjects. Daytime sleepiness and performance level following the night‐time administration of the drugs were assessed using Standford Sleepiness Scale (SSS), Sleep Evaluation Questionnaire (SEQ), Multiple Sleep Latency Test (MSLT), actigraphy recordings and Continuous Performance Test (CPT). Fifteen healthy volunteers… 
Retrograde effects of triazolam and zolpidem on sleep‐dependent motor learning in humans
Data indicate that non‐selective or α1‐preferring benzodiazepine site allosteric activators can interfere with sleep‐dependent memory consolidation.
Fármacos que pueden producir somnolencia excesiva
The description of the potential drug impact on the wake-sleep cycle is completed by referring the eventual effects that drug ingestion at morning time could induce during the night, highlighting the importance to consider the process as a continuum non-compart.
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  • 2003
The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety in order to keep subscribers up‐to‐date with the latest developments in their field.
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To assess whether actigraphy is sensitive to benzodiazepine‐induced changes in cognitive and psychomotor performance and sleep, a large number of mice were randomly assigned to either the “good” or “bad” groups.


Comparison of short and long half‐life benzodiazepine hypnotics: Triazolam and quazepam
The 0.25 mg dose of triazolam, which is being prescribed increasingly, has a profile of side effects that is similar to that of the 0.5 mg dose, and is associated with sleep and mood disturbances whereas quazepam exerted carryover effectiveness.
Daytime carryover of triazolam and flurazepam in elderly insomniacs.
It is suggested that, although both compounds improve nocturnal sleep in elderly insomniacs, there is significant residual sedation with flurazepam and improved daytime alertness with triazolam.
A repeated dose comparison of three benzodiazepine derivatives (nitrazepam, flurazepam and flunitrazepam) on subjective appraisals of sleep and measures of psychomotor performance the morning following night‐time medication
  • I. Hindmarch
  • Psychology, Medicine
    Acta psychiatrica Scandinavica
  • 1977
Evidence of a “rebound phenomenon” following 4 nights' withdrawal of active medication is shown in both subjective and objective measures of sleep and early morning behaviour.
Comparison of the effects of quazepam and triazolam on cognitive-neuromotor performance
Performance scores were already showing recovery from peak impairment 2 h post-drug ingestion, although quazepam's potent N-desalkylflurazepAM metabolite has been found to maintain a maximum plateau level from 2 to 24 h.
Daytime wakefulness following a bedtime oral dose of zolpidem 20 mg, flunitrazepam 2 mg and placebo.
Results indicate that zolpidem 20 mg is devoid of residual effects in a range of tasks that were sensitive enough to demonstrate a prolonged wakefulness impairment following flunitrzepam 2 mg in healthy volunteers.
Residual effects of repeated doses of 0.5 and 1 mg flunitrazepam
The EEG showed definite dose-related effects which tended to increase over the 8 nights of ingestion of the drug, and it was concluded that whereas the 1 mg dose may sometimes be associated with definite residual effects the next day, the 0.5 mg dose possesses positive qualities in producing useful subjective effects thenext day without appreciable impairment of psychological performance.
Quazepam and flurazepam: Long‐term use and extended withdrawal
The data suggest that the optimal dose of quazepam is 15 mg, and some loss of effectiveness was noted during long‐term use of both doses of quzepam and, to a lesser extent, of flurazepams.
Tolerance and rebound during and after short-term administration of quazepam, triazolam and placebo to healthy human volunteers.
  • A. Lee, M. Lader
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    International clinical psychopharmacology
  • 1988
Quazepam was associated with definite EEG effects, an unexpected improvement in simple motor performance and an increase in several bodily symptoms and ratings of sedation, and two symptom increases with triazolam might reflect day-time rebound.
Day-time residual effects and motor activity after three benzodiazepine hypnotics.
It is indicated that a small dose of a short-acting benzodiazepine may be appropriate for promoting sleep without subsequent day-time residual sequelae, in healthy, young subjects.
Effects of flunitrazepam on cognitive functions
The results indicate selective impairment of long-term memory in healthy young male volunteers, and the amnesic effect of flunitrazepam seems to be due to a decrease in the storage of memory traces.