Comparison of haemodynamic dose-response effects of beta- and alpha-beta-blockade in acute myocardial infarction.

@article{Silke1984ComparisonOH,
  title={Comparison of haemodynamic dose-response effects of beta- and alpha-beta-blockade in acute myocardial infarction.},
  author={Bernard Silke and Gregory I C Nelson and R. C. Ahuja and Charles Walker and Stanley Taylor},
  journal={International journal of cardiology},
  year={1984},
  volume={5 3},
  pages={317-25}
}
The comparative haemodynamic dose-response effects of beta- (propranolol) or alpha- plus beta-blockade (labetalol) were evaluated in a randomised between-group study of 16 patients with an uncomplicated acute myocardial infarction. In equivalent beta-blocking doses both drugs equally reduced myocardial stroke work index and presumably myocardial oxygen requirements. However, although propranolol reduced heart rate and cardiac output, these haemodynamic changes were accompanied by an… CONTINUE READING