Comparison of gravimetric and spectroscopic approaches to quantify stratum corneum removed by tape-stripping.

@article{Mohammed2012ComparisonOG,
  title={Comparison of gravimetric and spectroscopic approaches to quantify stratum corneum removed by tape-stripping.},
  author={Diar Mohammed and Qingliang Yang and Richard Guy and Paul Matts and Jonathan Hadgraft and Majella Lane},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2012},
  volume={82 1},
  pages={171-4}
}
Skin surface tape-stripping is an extensively used technique to examine the distribution profile, penetration and safety of various active compounds. It is also a widely accepted method to probe skin barrier properties and more specifically, those of the stratum corneum (SC). The amount of SC removed by tape-stripping is generally determined either gravimetrically or by extraction and measurement of SC proteins. A novel infra-red densitometry (IRD) technique has recently been introduced to… CONTINUE READING