Comparison of genetically encoded calcium indicators for monitoring action potentials in mammalian brain by two-photon excitation fluorescence microscopy.

@article{Podor2015ComparisonOG,
  title={Comparison of genetically encoded calcium indicators for monitoring action potentials in mammalian brain by two-photon excitation fluorescence microscopy.},
  author={Borbala Podor and Yi-ling Hu and Masamichi Ohkura and Junichi Nakai and Roger P Croll and Alan Fine},
  journal={Neurophotonics},
  year={2015},
  volume={2 2},
  pages={021014}
}
Imaging calcium transients associated with neuronal activity has yielded important insights into neural physiology. Genetically encoded calcium indicators (GECIs) offer conspicuous potential advantages for this purpose, including exquisite targeting. While the catalogue of available GECIs is steadily growing, many newly developed sensors that appear promising in vitro or in model cells appear to be less useful when expressed in mammalian neurons. We have, therefore, evaluated the performance of… CONTINUE READING
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