Comparison of genetic polymorphisms of CYP2E1, ADH2, and ALDH2 genes involved in alcohol metabolism in Koreans and four other ethnic groups.

@article{Kang2009ComparisonOG,
  title={Comparison of genetic polymorphisms of CYP2E1, ADH2, and ALDH2 genes involved in alcohol metabolism in Koreans and four other ethnic groups.},
  author={Tae Seok Kang and Sun Wook Woo and Hyun Joo Park and Y-f Lee and J N Roh},
  journal={Journal of clinical pharmacy and therapeutics},
  year={2009},
  volume={34 2},
  pages={225-30}
}
BACKGROUND AND OBJECTIVES Recent studies of the genetics of alcoholism have considered genetic factors in alcohol metabolism and have identified functional polymorphisms in genes encoding enzymes involved in ethanol metabolism. The aim of this study was to estimate the genotype and allele frequencies of polymorphisms of three major ethanol-metabolizing enzymes (ADH2, ALDH2 and CYP2E1) in Koreans and to compare them with those of other ethnic groups. METHODS We chose three polymorphisms, ADH2… CONTINUE READING
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