Comparison of gene therapy with the herpes simplex virus thymidine kinase gene and the bacterial cytosine deaminase gene for the treatment of hepatocellular carcinoma.

@article{Kuriyama1999ComparisonOG,
  title={Comparison of gene therapy with the herpes simplex virus thymidine kinase gene and the bacterial cytosine deaminase gene for the treatment of hepatocellular carcinoma.},
  author={Shigeki Kuriyama and Akira Mitoro and Masaharu Yamazaki and Hirohisa Tsujinoue and Tatsuya Nakatani and Takami Akahane and Yasunori Toyokawa and Hidefumi Kojima and Sachiko Okamoto and Hiroshi Fukui},
  journal={Scandinavian journal of gastroenterology},
  year={1999},
  volume={34 10},
  pages={1033-41}
}
BACKGROUND Bystander effects induced by suicide gene/prodrug systems play an essential role in achieving successful antitumor effects. Although it has been shown in several in vitro studies that the bacterial cytosine deaminase (CD) gene/5-fluorocytosine (5-FC) system is superior to the herpes simplex virus thymidine kinase (HSV-TK) gene/ganciclovir (GCV) system, we examined here which suicide gene system was more promising in vivo for the treatment of hepatocellular carcinoma (HCC). METHODS… CONTINUE READING
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