Comparison of gastric and intestinal antisecretory and protective effects of prostacyclin and its stable thia-imino-analogue (Hoe 892) in conscious rats.

  title={Comparison of gastric and intestinal antisecretory and protective effects of prostacyclin and its stable thia-imino-analogue (Hoe 892) in conscious rats.},
  author={Stanisław Jan Konturek and Tomasz Brzozowski and Tadeusz Radecki and I Pastucki},
  volume={28 4},
Actions and interactions of endothelins, prostacyclin and nitric oxide in the gastric mucosa.
  • B. Whittle, J. López-Belmonte
  • Biology, Medicine
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • 1993
Nitric oxide synthesized from L-arginine can regulate gastric mucosal blood flow, both under resting conditions and following stimulation of acid secretion, which has a critical interactive role in the physiological regulation of mucosal integrity.
PGI2 Inhibits Intestinal Epithelial Permeability and Apoptosis to Alleviate Colitis
Neuronal and endothelium‐derived mediators in the modulation of the gastric microcirculation: integrity in the balance
  • B. Whittle
  • Biology
    British journal of pharmacology
  • 1993
It will become apparent that local neuronal and endotheliumderived factors that affect the microcirculation have a crucial influence on the processes that allow the gastric mucosa to regulate microvascular blood flow in the gastic mucosa.
Gastric Mucosal Damage and Protection: Involvement of Novel Endothelium-Derived Mediators
The vascular endothelium synthesizes and releases a number of potent biologically active mediators that can exert both protective and injurious actions on the gastric mucosa. Such endogenous
Schädigung und Schutz der Magenschleimhaut: Beteiligung neuer, dem Endothel entstammender Faktoren
Das Gefasendothel ist der Ort von Synthese und Freisetzung einer Anzahl von wirksamen biologisch aktiven Mediatoren, die sowohl schutzende als auch schadigende Wirkung auf die Magenschleimhaut haben


Comparison of prostaglandin E2 and ranitidine in prevention of gastric bleeding by aspirin in man.
It is confirmed that oral PGE2 has a protective action on gastric mucosa exposed to aspirin and that this property is also shared by ranitidine, a potent histamine H2-receptor antagonist.
Distribution of prostaglandins in gastric and duodenal mucosa of healthy subjects and duodenal ulcer patients: effects of aspirin and paracetamol.
It is indicated that the gastric and duodenal mucosa is capable of generating PGE2-like activity which may be involved in the mechanism that protects the mucosa against the damage caused by aspirin.
Gastric cytoprotection in man by prostaglandin E2.
It is concluded that gastric cytoprotection by PGE2 in man might be mediated by stimulation of mucus and/or bicarbonate production.
Prostanoid synthesis by cultured gastric and duodenal mucosa: Possible role in the pathogenesis of duodenal ulcer.
Results suggest that a decrease in endogenous gastric prostanoid synthesis may have a role in the pathogenesis of peptic ulcer disease.
Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms.
  • T. Miller
  • Medicine, Biology
    The American journal of physiology
  • 1983
Findings suggest that prostaglandins may play a significant role in the pathogenesis of gastric ulceration and may serve an important function in maintaining normal gastric mucosal integrity.
Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa
Whether selective inhibition of prostaglandin production, assayed as PGE2-like activity, in the inflammatory exudate can be achieved in vivo is investigated and it is reported here that it can.