Comparison of gastric and intestinal antisecretory and protective effects of prostacyclin and its stable thia-imino-analogue (Hoe 892) in conscious rats.

@article{Konturek1984ComparisonOG,
  title={Comparison of gastric and intestinal antisecretory and protective effects of prostacyclin and its stable thia-imino-analogue (Hoe 892) in conscious rats.},
  author={Stanisław Jan Konturek and Tomasz Brzozowski and Tadeusz Radecki and I Pastucki},
  journal={Prostaglandins},
  year={1984},
  volume={28 4},
  pages={
          443-53
        }
}
Actions and interactions of endothelins, prostacyclin and nitric oxide in the gastric mucosa.
  • B. Whittle, J. López-Belmonte
  • Biology, Medicine
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • 1993
TLDR
Nitric oxide synthesized from L-arginine can regulate gastric mucosal blood flow, both under resting conditions and following stimulation of acid secretion, which has a critical interactive role in the physiological regulation of mucosal integrity.
PGI2 Inhibits Intestinal Epithelial Permeability and Apoptosis to Alleviate Colitis
Neuronal and endothelium‐derived mediators in the modulation of the gastric microcirculation: integrity in the balance
  • B. Whittle
  • Biology
    British journal of pharmacology
  • 1993
TLDR
It will become apparent that local neuronal and endotheliumderived factors that affect the microcirculation have a crucial influence on the processes that allow the gastric mucosa to regulate microvascular blood flow in the gastic mucosa.
Gastric Mucosal Damage and Protection: Involvement of Novel Endothelium-Derived Mediators
The vascular endothelium synthesizes and releases a number of potent biologically active mediators that can exert both protective and injurious actions on the gastric mucosa. Such endogenous
Schädigung und Schutz der Magenschleimhaut: Beteiligung neuer, dem Endothel entstammender Faktoren
Das Gefasendothel ist der Ort von Synthese und Freisetzung einer Anzahl von wirksamen biologisch aktiven Mediatoren, die sowohl schutzende als auch schadigende Wirkung auf die Magenschleimhaut haben

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