Comparison of functional properties of mammalian DNA polymerase lambda and DNA polymerase beta in reactions of DNA synthesis related to DNA repair.

@article{Lebedeva2005ComparisonOF,
  title={Comparison of functional properties of mammalian DNA polymerase lambda and DNA polymerase beta in reactions of DNA synthesis related to DNA repair.},
  author={Natalia A. Lebedeva and Nadejda I. Rechkunova and Sergey V. Dezhurov and Svetlana N. Khodyreva and A. Favre and Luis Blanco and Olga D Zakharova},
  journal={Biochimica et biophysica acta},
  year={2005},
  volume={1751 2},
  pages={150-8}
}
DNA polymerase lambda (Pol lambda) is a novel enzyme of the family X of DNA polymerases. Pol lambda has some properties in common with DNA polymerase beta (Pol beta). The substrate properties of Pol lambda were compared to Pol beta using DNAs mimicking short-patch (SP) and long-patch (LP) base excision repair (BER) intermediates as well as recessed template primers. In the present work, the influence of several BER proteins such as flap-endonuclease-1 (FEN1), PCNA, and apurinic/apyrimidinic… CONTINUE READING