Comparison of functional outcomes and quality of life between transoral surgery and definitive chemoradiotherapy for oropharyngeal cancer

  title={Comparison of functional outcomes and quality of life between transoral surgery and definitive chemoradiotherapy for oropharyngeal cancer},
  author={Allen M. Chen and Megan E. Daly and Quang C. Luu and Paul J. Donald and Donald Gregory Farwell},
  journal={Head \& Neck},
The purpose of this study was to compare patient‐reported outcomes between patients treated by initial transoral resection versus definitive chemoradiotherapy for oropharyngeal cancer. 

Patterns of local recurrence after curative resection and reconstruction for oropharyngeal and oral cancers: Implications for postoperative radiotherapy target volumes

We aimed to determine the patterns of local recurrence after curative resection and reconstruction for oropharyngeal and oral cancers.

Association of comorbidity score with perioperative outcomes following transoral robotic surgery: National analysis

The association of comorbidities with perioperative outcomes after transoral robotic surgery (TORS) is not well‐defined in the literature.

Functional swallowing outcomes following treatment for oropharyngeal carcinoma: a systematic review of the evidence comparing trans‐oral surgery versus non‐surgical management

  • N. DaweJ. PattersonJ. O’Hara
  • Medicine
    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • 2016
Trans‐oral surgical and non‐surgical management options for oropharyngeal squamous cell carcinoma appear to offer similar survival outcomes, and functional outcomes have become of increasing interest in the debate regarding treatment options.

Treatments for locally advanced oropharyngeal cancer: A systematic review of clinical effectiveness and cost-effectiveness.

The superiority of primary surgery versus primary concurrent chemoradiotherapy (CRT) in the treatment of locally advanced oropharyngeal cancer (LAOPC) is not apparent and this system should be considered for further studies.

Meta‐analysis on survival of patients treated with transoral surgery versus radiotherapy for early‐stage squamous cell carcinoma of the oropharynx

Comparison of the currently available data on survival provided by TOS versus RT for patients with early stage oropharyngeal squamous cell carcinoma is compared.

Minimizing adjuvant treatment after transoral robotic surgery through surgical margin revision and exclusion of radiographic extracapsular extension: A Prospective observational cohort study

It is investigated in a prospective cohort of patients treated with TORS for oropharyngeal cancer, who were selected for the absence of radiographic extra‐capsular extension, the possibility of reducing adjuvant radiation (RT)/chemo‐radiation therapy (CRT) without jeopardizing tumor control and functional outcome.

Treatment modality impact on quality of life for human papillomavirus–associated oropharynx cancer

Compare treatment‐related quality of life (QOL) impact for early‐stage human papillomavirus–associated oropharynx squamous cell carcinoma (HPV+ OPSCC) patients.

Primary Surgical Management of Oropharyngeal Squamous Cell Carcinoma

The most recent literature regarding the use of TORS and TLM in the surgical management of OPSCC is reviewed, with a focus on indications, oncologic, and functional outcomes.

Quality of Life Implications in Head and Neck Cancer

Quality of life is a multidimensional subjective concept which is an important consideration in head and neck cancer treatment and may be a component of outcome assessment following treatment often overlooked by treating physicians.



Transoral robotic surgery for oropharyngeal carcinoma and its impact on patient‐reported quality of life and function

The aim of this study was to assess the quality of life of patients with oropharyngeal squamous cell carcinoma after transoral robotic surgery (TORS).

Transoral robotic surgery for oropharyngeal squamous cell carcinoma: A prospective study of feasibility and functional outcomes

To investigate the feasibility of transoral robotic surgery as a method of surgical treatment of oropharyngeal squamous cell carcinoma.

Carcinoma of the Tongue Base Treated by Transoral Laser Microsurgery, Part One: Untreated Tumors, a Prospective Analysis of Oncologic and Functional Outcomes

Objectives: To report the oncologic and functional outcomes of transoral laser microsurgery (TLM) in the management of untreated primary carcinoma of the tongue base.

Swallowing function after transoral laser microsurgery (TLM) ± adjuvant therapy for advanced‐stage oropharyngeal cancer

To perform a longitudinal description of swallowing function following transoral laser microsurgery (TLM) ± adjuvant therapy for advanced‐stage oropharyngeal cancer (OPC) and identify prognostic

Examination of laryngoesophageal dysfunction‐free survival as an endpoint in nonsurgical treatment of squamous cell carcinomas of the larynx and hypopharynx

A recently published consensus guideline suggested a new endpoint for clinical trials involving cancer of the larynx and hypopharynx: laryngoesophageal dysfunction‐free survival (LEDFS). The authors

Assessment of quality of life in head and neck cancer patients

The new test was compared to two established equality of life evaluation tools, the Karnofsky scale and the Sickness Impact Profile (SIP).

Functional swallowing outcomes following transoral robotic surgery vs primary chemoradiotherapy in patients with advanced-stage oropharynx and supraglottis cancers.

Advanced-stage oropharynx and supraglottis cancers managed by transoral robotic surgery with adjuvant therapy resulted in significantly better swallowing MDADI outcomes at the follow-up visits at 6 and 12 months compared with tumors treated by primary chemoradiotherapy.

Patient-perceived and objective functional outcomes following transoral robotic surgery for early oropharyngeal carcinoma.

After TORS-assisted resection of T1 and T2 oropharyngeal squamous cell carcinomas, approximately one-third of patients will experience a sustained decrease in perceived swallowing function, however, ongoing improvement of swallowing function over time is likely even after 12 months.

Quality-of-Life Outcomes in Transoral Robotic Surgery

The preliminary data show that patients who undergo TORS for malignancies and receive adjuvant therapy tend to have lower HRQOL outcomes.

Transoral laser microsurgery for squamous cell carcinoma of the base of the tongue.

The concept of organ and function preserving laser microsurgery for selected patients with base of tongue cancer seems to be justified considering the achieved oncological and functional results.