Comparison of fluorescence in situ hybridization, p57 immunostaining, flow cytometry, and digital image analysis for diagnosing molar and nonmolar products of conception.

@article{Kipp2010ComparisonOF,
  title={Comparison of fluorescence in situ hybridization, p57 immunostaining, flow cytometry, and digital image analysis for diagnosing molar and nonmolar products of conception.},
  author={Benjamin R. Kipp and Rhett P. Ketterling and Trynda N Oberg and Margot A Cousin and Amy M Plagge and Anne E. Wiktor and Johnita M Ihrke and Cecelia H Meyers and William G. Morice and Kevin C. Halling and Amy C. Clayton},
  journal={American journal of clinical pathology},
  year={2010},
  volume={133 2},
  pages={196-204}
}
Pathologic examination of products of conception (POC) is used to differentiate hydropic abortus (HA), partial hydatidiform mole (PM), and complete hydatidiform mole (CM). Histologic classification of POC specimens can be difficult, and ancillary testing is often required for a definitive diagnosis. This study evaluated 66 POC specimens by flow cytometry, digital image analysis, p57 immunohistochemical analysis, and fluorescence in situ hybridization (FISH). The final diagnosis, based on the… CONTINUE READING

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