Comparison of five bifunctional chelate techniques for 90Y-labeled monoclonal antibody CO17-1A.

@article{Washburn1991ComparisonOF,
  title={Comparison of five bifunctional chelate techniques for 90Y-labeled monoclonal antibody CO17-1A.},
  author={Lee C. Washburn and Tim Thomas Sun and Yong Chul Lee and B L Byrd and Esteban Jaimovich Collegio Carlo Alberto Juan Pablo Rud Ro Holloway and James Crook and James B. Stubbs and Michael G. Stabin and Martin W. Brechbiel and Otto A. Gansow},
  journal={International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology},
  year={1991},
  volume={18 3},
  pages={
          313-21
        }
}
Monoclonal antibody CO17-1A was radiolabeled with 90Y by five bifunctional chelate techniques. Radiation absorbed dose estimates for normal organs and tumor were calculated for each preparation based on timed tissue distribution studies in nude mice bearing SW 948 human colorectal carcinoma xenografts. The cyclic DTPA anhydride technique was inferior to the four other techniques studied. Data for SCN-Bz-DTPA and SCN-Bz-Mx-DTPA, which were conjugated to epsilon-lysyl amino groups, were similar… CONTINUE READING