Comparison of family histories in FTLD subtypes and related tauopathies

  title={Comparison of family histories in FTLD subtypes and related tauopathies},
  author={Jill S Goldman and Jennifer M. Farmer and Elisabeth Mccarty Wood and J. K. Johnson and Adam L. Boxer and John M. Neuhaus and Catherine Lomen‐Hoerth and Kirk C. Wilhelmsen and Virginia M. -Y. Lee and Murray Grossman and Bruce L. Miller},
  pages={1817 - 1819}
Pedigrees from 269 patients with frontotemporal lobar degeneration (FTLD), including frontotemporal dementia (FTD), FTD with ALS (FTD/ALS), progressive nonfluent aphasia, semantic dementia (SD), corticobasal degeneration, and progressive supranuclear palsy were analyzed to determine the degree of heritability of these disorders. FTD/ALS was the most and SD the least heritable subtype. FTLD syndromes appear to have different etiologies and recurrence risks. 

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Current knowledge about mutations at the basis of familial FTLD will be described, together with genetic risk factors influencing the susceptibility to FTLD.

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