Comparison of experimental and theoretical parameters of the Moolgavkar-Venzon-Knudson incidence function for the stages of initiation and promotion in rat hepatocarcinogenesis.

@article{Dragan1995ComparisonOE,
  title={Comparison of experimental and theoretical parameters of the Moolgavkar-Venzon-Knudson incidence function for the stages of initiation and promotion in rat hepatocarcinogenesis.},
  author={Yvonne P. Dragan and J R Hully and K. Baker and Rosemary Crow and Marc J. Mass and Henry C. Pitot},
  journal={Toxicology},
  year={1995},
  volume={102 1-2},
  pages={161-75}
}
Mathematical descriptions of complex biological phenomena, such as cancer, require an experimental format that faithfully recapitulates the biological process. In addition, the biological process must dictate the parameters in the mathematical formula. Evidence from the epidemiology of several human cancers and from experimental carcinogenesis in several organ systems indicates that cancer is a multistage process. The initiation-promotion-progression format of experimental carcinogenesis mimics… CONTINUE READING