Comparison of evidence of treatment effects in randomized and nonrandomized studies.

@article{Ioannidis2001ComparisonOE,
  title={Comparison of evidence of treatment effects in randomized and nonrandomized studies.},
  author={J. Ioannidis and A. Haidich and M. Pappa and N. Pantazis and S. I. Kokori and M. Tektonidou and D. Contopoulos-Ioannidis and J. Lau},
  journal={JAMA},
  year={2001},
  volume={286 7},
  pages={
          821-30
        }
}
  • J. Ioannidis, A. Haidich, +5 authors J. Lau
  • Published 2001
  • Medicine
  • JAMA
  • CONTEXT There is substantial debate about whether the results of nonrandomized studies are consistent with the results of randomized controlled trials on the same topic. OBJECTIVES To compare results of randomized and nonrandomized studies that evaluated medical interventions and to examine characteristics that may explain discrepancies between randomized and nonrandomized studies. DATA SOURCES MEDLINE (1966-March 2000), the Cochrane Library (Issue 3, 2000), and major journals were searched… CONTINUE READING
    713 Citations

    Figures, Tables, and Topics from this paper

    Explore Further: Topics Discussed in This Paper

    Meta-analytic comparison of randomized and nonrandomized studies of breast cancer surgery.
    • 14
    • PDF
    Comparison of evidence on harms of medical interventions in randomized and nonrandomized studies
    • 232
    • PDF
    Assessing observational studies of medical treatments
    • 35
    • Highly Influenced

    References

    SHOWING 1-10 OF 66 REFERENCES
    A comparison of observational studies and randomized, controlled trials
    • Benson, Hartz
    • Medicine
    • American journal of ophthalmology
    • 2000
    • 1,408
    Randomized, controlled trials, observational studies, and the hierarchy of research designs.
    • 3,042
    How study design affects outcomes in comparisons of therapy. I: Medical.
    • 491
    • PDF
    Randomized versus historical controls for clinical trials.
    • 737
    • Highly Influential
    • PDF
    Publication bias in clinical research
    • 2,555
    How study design affects outcomes in comparisons of therapy. II: Surgical.
    • 86
    • PDF