Comparison of estimation algorithms in single-molecule localization.

  title={Comparison of estimation algorithms in single-molecule localization.},
  author={Anish V. Abraham and Sripad Ram and Jerry Chao and E Sally Ward and Raimund J. Ober},
  journal={Proceedings of SPIE--the International Society for Optical Engineering},
Different techniques have been advocated for estimating single molecule locations from microscopy images. The question arises as to which technique produces the most accurate results. Various factors, e.g. the stochastic nature of the photon emission/detection process, extraneous additive noise, pixelation, etc., result in the estimated single molecule location deviating from its true location. Here, we review the results presented by [Abraham et. al, Optics Express, 2009, 23352-23373], where… CONTINUE READING