Comparison of esmolol and nitroprusside for acute post-cardiac surgical hypertension.

@article{Gray1987ComparisonOE,
  title={Comparison of esmolol and nitroprusside for acute post-cardiac surgical hypertension.},
  author={Richard Gray and Timothy M. Bateman and Lawrence S. C. Czer and Craig Conklin and Jack M. Matloff},
  journal={The American journal of cardiology},
  year={1987},
  volume={59 8},
  pages={887-91}
}
Because acute systemic hypertension early after cardiac surgery has been linked to catecholamine elevation, an open-label, randomized, crossover study was performed to compare the efficacy of esmolol, a new ultra-short-acting intravenous beta-blocking agent, to nitroprusside, the standard therapy. Controlled drug infusions to maximal dosage (esmolol, 300 micrograms/kg/min, and nitroprusside, 10 micrograms/kg/min) were titrated to achieve at least a 15% reduction in systolic pressure. The blood… CONTINUE READING

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