Comparison of epicutaneous patch testing with synovial T-cell infiltration in patients with arthroplasty: an immunohistological examination to clarify allergic reactions to metallic implants at the synovial membrane

@article{Laupheimer2004ComparisonOE,
  title={Comparison of epicutaneous patch testing with synovial T-cell infiltration in patients with arthroplasty: an immunohistological examination to clarify allergic reactions to metallic implants at the synovial membrane},
  author={Markus Wilhelm Laupheimer and Dorothee Riescher and Manfred Thomas and Thomas M. Wagner and Hans Martin Arnholdt and Thomas Naumann},
  journal={European Journal of Orthopaedic Surgery & Traumatology},
  year={2004},
  volume={14},
  pages={67-71}
}
To find evidence of hypersensitivity reactions after arthroplasty as a possible cause for aseptic loosening, 35 patients were patch tested before surgery. To identify the cellular basis of a delayed-type hypersensitivity reaction, we histologically evaluated samples of synovial membranes from the hip or knee. For further evaluation of the cellular response, we tested for CD3, CD4, CD8, and NK cells. The samples were taken during revision of aseptic loosening, primary arthroplasty, or secondary… CONTINUE READING