Comparison of endothelium-related responses to nucleotides of dog and monkey cerebral arteries.

Abstract

We compared mechanical responses to uridine-5'triphosphate (UTP) and 2-(methylthio)adenosine-5'diphosphate (2MeSADP) of cerebral arteries isolated from dogs and monkeys. In the dog, UTP induced endothelium-independent contraction, whereas 2MeSADP induced endothelium-dependent relaxation that was abolished by N(G)-nitro-L-arginine (L-NA). In the monkey, both… (More)

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