Comparison of enalapril and captopril in the management of self-induced water intoxication

  title={Comparison of enalapril and captopril in the management of self-induced water intoxication},
  author={C. Simon Sebastian and Amor S. Bernardin},
  journal={Biological Psychiatry},
Problems and progress in the diagnosis and treatment of polydipsia and hyponatremia.
Case reports and open studies have shown that clozapine improves both polydipsia and water retention, but the response occurs at low doses and is not related to improvement in psychosis.
Treatment of Psychogenic Polydipsia With Acetazolamide: A Report of 5 Cases
Acetazolamide appears to have a beneficial effect in psychogenic polydipsia, which occurs frequently in patients with chronic psychiatric illness and is often unmanageable.
Is Propranolol Effective in Primary Polydipsia?
It is suggested that propranolol may be useful for the treatment of polydipsia in patients with schizophrenia because its efficacy could be related to inhibition of the renin-angiotensin system.
Treatment of Psychogenic Polydipsia: Comparison of Risperidone and Olanzapine, and the Effects of an Adjunctive Angiotensin-II Receptor Blocking Drug (Irbesartan)
It is suggested that the D2-sparing profiles of receptor binding achieved with low-dose risperidone and olanzapine may account for this beneficial effect, and the benefit derived with irbesartan implicates the involvement of brain angiotensin systems centrally in helping to regulate drinking behaviour.
Neuroendocrine Factors Influencing Polydipsia in Psychiatric Patients: An Hypothesis
An etiological model and a treatment modality for polydipsia are suggested and angiotensin II releases vasopressin; this could explain water intoxication, which occurs later in the syndrome.
Polyuria and Polydipsia
The water deprivation test is an established test to differentiate between cranial and renal DI, and synthetic ADH still remains the treatment of choice for cranial DI.
Psychogenic polydipsia review: Etiology, differential, and treatment
Evaluation of psychiatric patients with polydipsia warrants a comprehensive evaluation for other medical causes of polyd dipsia, polyuria, hyponatremia, and the syndrome of inappropriate secretion of antidiuretic hormone.


Hyposthenuria as a marker for self-induced water intoxication and schizophrenic disorders.
Four patients with the syndrome of self-induced water intoxication and schizophrenic disorders, as well as inappropriate antidiuresis, are described, and severe hyposthenuria may be a marker for this syndrome.
Water excretion and plasma vasopressin in psychotic disorders.
Patients whose current illness had lasted less than 24 weeks exhibited the most severe antidiuretic state and also had the highest plasma arginine vasopressin levels.
Mechanisms of altered water metabolism in psychotic patients with polydipsia and hyponatremia.
It is concluded that psychiatric patients with polydipsia and hyponatremia have unexplained defects in urinary dilution, the osmoregulation of water intake, and the secretion of vasopressin.
Somatic findings in patients with psychogenic polydipsia.
An epidemiologic investigation found a 17.5% prevalence of psychogenic polydipsia in 241 hospitalized psychiatric patients and revealed such associated disorders as sporadic convulsive seizures, comatose states, hydronephrosis, enuresis/urinary incontinence, projectile type vomiting, malnutrition and, in one case, cardiomegaly and edema.
Effects of captopril on psychosis and disturbed water regulation.
Water homeostasis in psychiatric patients