Comparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays.

@article{Harris2013ComparisonOE,
  title={Comparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays.},
  author={Kate Harris and Mike Aylott and Yi Cui and James B Louttit and Nicholas C McMahon and Arun Sridhar},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2013},
  volume={134 2},
  pages={412-26}
}
Human-induced pluripotent stem cell cardiomyocytes (hiPSC-CMs) are a potential source to develop assays for predictive electrophysiological safety screening. Published studies show that the relevant physiology and pharmacology exist but does not show the translation between stem cell cardiomyocyte assays and other preclinical safety screening assays, which is crucial for drug discovery and safety scientists and the regulators. Our studies are the first to show the pharmacology of ion channel… CONTINUE READING

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