Comparison of electrocardiographic analysis for risk of QT interval prolongation using safety pharmacology and toxicological studies.

@article{Guth2009ComparisonOE,
  title={Comparison of electrocardiographic analysis for risk of QT interval prolongation using safety pharmacology and toxicological studies.},
  author={Brian D. Guth and Alan S Bass and Richard V. Briscoe and Simon Chivers and Michael Markert and Peter K. S. Siegl and J-P Valentin},
  journal={Journal of pharmacological and toxicological methods},
  year={2009},
  volume={60 2},
  pages={107-16}
}
Testing for possible cardiovascular side effects of new drugs has been an essential part of drug development for years. A more detailed analysis of the electrocardiogram (ECG) to detect effects on ventricular repolarization (effects on the QT interval), as a marker for possible proarrhythmic potential has been added to that evaluation in recent years. State-of-the art evaluation of drug-induced effects on the QT interval have evolved, but due to the complexity of the assessment, the trend in… CONTINUE READING

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