Comparison of efficacy of products containing azelaic acid in melasma treatment

  title={Comparison of efficacy of products containing azelaic acid in melasma treatment},
  author={Klaudia Mazurek and Ewa Pierzchała},
  journal={Journal of Cosmetic Dermatology},
Melasma is one of the most frequently diagnosed hyperpigmentation changes on the skin of women's faces. Nearly 30% of women using oral estrogen therapy struggle with this problem. A common way of reducing melasma is the application of azelaic acid products. 

Azelaic Acid in Acne Vulgaris

The mechanism of action, usage, and alternative options of the medication azelaic acid are discussed.

Medical Management of Melasma: A Review with Consensus Recommendations by Indian Pigmentary Expert Group

The article discusses available evidence and brings forward a suggested treatment algorithm by experts from Pigmentary Disorders Society (PDS) in a collaborative discussion called South Asian pigmentary Forum (SPF).

Melasma treatment: a systematic review

Treatment choice should be made after Wood’s lamp examination, as well as dermatoscopic evaluation, in order to select the best treatment option, targeted at each melasma subtype, when compared to single terapies.

The versatility of azelaic acid in dermatology

This review found the strongest evidence supporting the use of azelaic acid in rosacea, followed by its use off-label in melasma followed by acne vulgaris.

Understanding Melasma-How Can Pharmacology and Cosmetology Procedures and Prevention Help to Achieve Optimal Treatment Results? A Narrative Review

It is shown that in-depth knowledge associated with proper communication and the establishment of a relationship with the patient help to achieve good adherence and compliance in this long-term, time-consuming and difficult procedure.

The top 10 cosmeceuticals for facial hyperpigmentation

Possible safer and more efficacious cosmeceutical therapies the authors discuss include thiamidol, kojic acid, vitamin C, arbutin, retinol, nicotinamide, ferulic acid, resorcinol, licorice root extract, and soy.

Melasma: Update on Epidemiology, Clinical Presentation, Assessment, and Scoring

Emphasis has been laid on melasma's epidemiological and clinical aspects and its assessment and scoring in this review.

Facial Hyperpigmentation in Skin of Color: Special Considerations and Treatment

Facial hyperpigmentation is one of the most common skin disorders and treatment options in people of color and the challenge for clinicians is to establish correct diagnoses along with consistently successful treatments.

Emerging topical therapies to treat pigmentary disorders: an evidence-based approach

Varying levels of evidence support the use of topicals in treating hyperpigmentation, and careful monitoring and adjustment of doses will be needed to maximize skin lightening benefits and minimize side effects.

Neue Therapien der Hyperpigmentierung am Horizont?

  • Miriam Sonnet
  • Medicine
    ästhetische dermatologie & kosmetologie
  • 2019
Goldstandard für die Behandlung von Pigmentunregelmäßigkeiten der Haut ist nach wie vor Hydrochinon. Aber auch andere Therapien, wie plättchenreiches Plasma, sind in Sicht — deren Wirksamkeit muss



The Treatment of Melasma 20% Azelaic Acid versus 4% Hydroquinone Cream

Abstract: The efficacy of 20% azelaic acid cream and 4% hydroquinone cream, both used in conjunction with a broad‐spectrum sunscreen, against melasma was investigated in a 24‐week, double‐blind study

Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma.

The clinical efficacy of azelaic acid and hydroquinone creams in the treatment of melasma was compared in a randomized, double-blind study with 155 patients of Indo-Malay-Hispanic origin, finding good to excellent overall results.

Melasma in men: a clinical, aetiological and histological study

There are hardly any studies delineating the clinical, aetiological and histological features of melasma in men and the present study was taken up to fill this lacuna.

Recurrent lentigo maligna melanoma: regression associated with local azelaic acid 20%.

A case of a patient with local recurrence of a stage IV lentigo maligna melanoma of the cheek which cleared after treatment with azelaic acid cream 20% is reported.

Melasma: histopathological characteristics in 56 Korean patients

Melasma is a common acquired symmetrical hypermelanosis characterized by irregular light to dark brown macules and patches on sun‐exposed areas of the skin that is not fully understood.

Melanin hyperpigmentation of skin: melasma, topical treatment with azelaic acid, and other therapies.

Destruction of malignant melanocytes by a combination of the same activities, enhanced by the greater permeability of tumoral cells to azelaic acid, may account for the clinical effects of azelaing acid observed in lentigo maligna and individual lesions of primary melanoma.

Efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from European clinical trials and experimental reports.

Comparisons with clinically proven therapies have shown that 20 percent AzA cream is an effective monotherapy in mild to moderate forms of acne, with an overall efficacy comparable to that of tretinoin, benzoyl peroxide, and topical erythromycin.


Azelaic acid was chosen for further investigation and development of a new topical drug for treating hyperpigmentary disorders for the following reasons: it possesses a middle-range of antityrosinase activity, is inexpensive, and more soluble to be incorporated into a base creatn than other dicarboxylic acids.

Azelaic acid modulates the inflammatory response in normal human keratinocytes through PPARγ activation

Azelaic acid modulates the inflammatory response in normal human keratinocytes through PParγ activation through PPARγ activation.