Comparison of efficacies of famciclovir and valaciclovir against herpes simplex virus type 1 in a murine immunosuppression model.

@article{Field1995ComparisonOE,
  title={Comparison of efficacies of famciclovir and valaciclovir against herpes simplex virus type 1 in a murine immunosuppression model.},
  author={Hugh J. Field and Deepanker Tewari and Debbie Sutton and Alana M Thackray},
  journal={Antimicrobial agents and chemotherapy},
  year={1995},
  volume={39 5},
  pages={1114-9}
}
A mouse model of herpes simplex virus type 1 infection in an immunocompromised host was established by using cyclosporin-A to impair T-cell function. Following inoculation of herpes simplex virus type 1 into the skin of the ear pinna, cyclosporin-A prolonged virus replication in the skin and neural tissues compared with that in immunocompetent mice. This model was used to investigate the activity of famciclovir (FCV) and valaciclovir (VACV), which are oral products of the antiherpesvirus agents… CONTINUE READING
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