Comparison of efficacies of cysteine protease inhibitors against five strains of Plasmodium falciparum.

@article{Singh2001ComparisonOE,
  title={Comparison of efficacies of cysteine protease inhibitors against five strains of Plasmodium falciparum.},
  author={Ajay Singh and Philip J. Rosenthal},
  journal={Antimicrobial agents and chemotherapy},
  year={2001},
  volume={45 3},
  pages={949-51}
}
Falcipain-2, a cysteine protease and essential hemoglobinase of Plasmodium falciparum, is a potential antimalarial drug target. We compared the falcipain-2 sequences and sensitivities to cysteine protease inhibitors of five parasite strains that differ markedly in sensitivity to established antimalarial drugs. The sequence of falcipain-2 was highly conserved, and the sensitivities of all of the strains to falcipain-2 inhibitors were very similar. Thus, cross-resistance between cysteine protease… CONTINUE READING

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