Comparison of effects of phorbol esters and glucose on protein kinase C activation and insulin secretion in pancreatic islets.

@article{Easom1989ComparisonOE,
  title={Comparison of effects of phorbol esters and glucose on protein kinase C activation and insulin secretion in pancreatic islets.},
  author={Richard A Easom and J. S. Hughes and Michael L Landt and Bryan A. Wolf and Jed Turk and Michael L. McDaniel},
  journal={The Biochemical journal},
  year={1989},
  volume={264 1},
  pages={27-33}
}
The tumour-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) induces insulin secretion from isolated pancreatic islets, and this suggests a potential role for protein kinase C in the regulation of stimulus-secretion coupling in islets. In the present study, the hypothesis that the insulinotropic effect of TPA is mediated by activation of… CONTINUE READING